| JLB Early View - June 2022 |
ARTICLES Acteoside promotes B cell‐derived IL‐10 production and ameliorates autoimmunity Meiling Wu, Sulan Yu, Yacun Chen, Wei Meng, Haiyong Chen, Jing He, Jiangang Shen, Xiang Lin
Version of Record online:31 May 2022  Graphical Abstract Acteoside promotes IL-10-producing capacity of B cells in a TLR4/PI3K dependent manner, and thus restores regulatory B cell function during autoimmune progression. ARTICLES A high‐calorie diet aggravates LPS‐induced pneumonia by disturbing the gut microbiota and Th17/Treg balance Hui Liu, Chen Bai, Fuyang Xian, Shaoyang Liu, Chaojun Long, Li Hu, Tiegang Liu, Xiaohong Gu
Version of Record online:31 May 2022  Graphical Abstract A high-calorie diet can potentially reset the gut microbiome and metabolites, disrupt Th17/Treg cell balance and aggravate LPS-induced lung inflammatory damage.  Open Access
HIGHLIGHTED ARTICLE Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes Louisa V Ashby, Reuben Springer, Vu Van Loi, Haike Antelmann, Mark B Hampton, Anthony J Kettle, Nina Dickerhof
Version of Record online:27 May 2022  Graphical Abstract Bacterial bacillithiol was oxidized during phagocytosis but provided minimal protection against the neutrophil's killing mechanisms.  Free Access
COVID-19 SPECIAL SECTION Highly restricted SARS‐CoV‐2 receptor expression and resistance to infection by primary human monocytes and monocyte‐derived macrophages Urvi Zankharia, Anjana Yadav, Yanjie Yi, Beatrice H. Hahn, Ronald G. Collman
Version of Record online:27 May 2022  Graphical Abstract Monocytes and monocyte-derived macrophages express minimal ACE2 and TMPRSS2 and resist SARS-CoV-2 Spike-mediated infection, suggesting direct myeloid cell infection is unlikely a major contributor to pathogenesis. REVIEW 2022 update on the scientific premise and clinical trials for IL‐15 agonists as cancer immunotherapy Yingjun Peng, Shengyu Fu, Qi Zhao
Version of Record online:26 May 2022  Graphical Abstract Interleukin-15 agonists offer a new therapeutic option in the future direction of cancer immunotherapy. Free Access
ERRATUM ERRATUMVersion of Record online:25 May 2022
REVIEWS Leukocyte modulation by natural products from herbal medicines and potential as cancer immunotherapy Huihai Yang, Lulu Wang, Jing Zhang
Version of Record online:25 May 2022  Graphical Abstract Herbal medicines have been shown to have great potential as natural products able to enhance tumor immunotherapy, serving a suppressive role in tumor progression and metastasis. Open Access
MEETING REVIEWS Advancing basic and translational research to deepen understanding of the molecular immune‐mediated mechanisms regulating long‐term persistence of HIV‐1 in microglia in the adult human brain Thomas Boucher, Shijun Liang, Amanda M. Brown
Version of Record online:25 May 2022  Graphical Abstract Review focuses on human post-mitotic monocyte-derived microglia-like cells as tools to advance research on HIV persistence and neuroinflammatory signaling. Open Access
ARTICLES Notch regulates Histoplasma capsulatum clearance in mouse lungs during innate and adaptive immune response phases in primary infection Shuo Huang, George S. Deepe Jr.
Version of Record online:23 May 2022  Graphical Abstract Notch signaling dictates the function of dendritic cells and monocytes/macrophages in fungal infection. REVIEW Metabolic regulation of type 2 immune response during tissue repair and regeneration Tian Ding, Shaohua Ge
Version of Record online:23 May 2022  Graphical Abstract Review on the metabolic regulation of immune cells involved in type 2 immunity and the role of these cells in tissue repair. Open Access
BRIEF CONCLUSIVE REPORT IL‐7 induces type 2 cytokine response in lung ILC2s and regulates GATA3 and CD25 expression Abdalla Sheikh, Julia Lu, Etienne Melese, Jung Hee Seo, Ninan Abraham
Version of Record online:23 May 2022  Graphical Abstract IL-7 is required for optimal IL-5, IL-13 and amphiregulin production in ILC2s during influenza/A infection; additionally, IL-7 regulates GATA3 in lung and bone marrow ILC2s. ARTICLES Sophoridine inhibits endotoxin‐induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation Jinping Liang, Juntong Liu, Yezhen Tang, Qian Peng, Ling Zhang, Xiaoxia Ma, Nan Xu, Jun Wei, Huaiqin Han
Version of Record online:23 May 2022  Graphical Abstract Sophoridine may inhibit endotoxin-induced ALI by enhancing the autophagy of macrophages and reducing inflammation. The mechanism may be related to sophoridine downregulated the expression of TLR4/MyD88/NF and mTOR. Open Access
REVIEW Macrophage orchestration of epithelial and stromal cell homeostasis in the intestine Qian Cao, Randall Tyler Mertens, Kisha Nandini Sivanathan, Xuechun Cai, Peng Xiao
Version of Record online:20 May 2022  Graphical Abstract This review focuses on how macrophages regulate intestine inflammation through cross-talking with epithelial cells and mesenchymal cells in the gut. ARTICLES Dysregulation of the IFN‐I signaling pathway by Mycobacterium tuberculosis leads to exacerbation of HIV‐1 infection of macrophages Maeva Dupont, Stella Rousset, Thien-Phong Vu Manh, Sarah Catherine Monard, Karine Pingris, Shanti Souriant, Zoï Vahlas, Tomàs Velez, Renaud Poincloux, Isabelle Maridonneau-Parini I, Olivier Neyrolles, Geanncarlo Lugo-Villarino, Christel Vérollet
Version of Record online:19 May 2022  Graphical Abstract Here, we identify a mechanism to explain why TB-derived type I-IFN is not able to induce antiviral immunity against HIV-1 in macrophages. Open Access
ARTICLES HIV‐1‐induced type I IFNs promote viral latency in macrophages Laura L. Dickey, Laura J. Martins, Vicente Planelles, Timothy M. Hanley
Version of Record online:19 May 2022  Graphical Abstract The molecular mechanisms by which macrophages induce HIV-1 latency were identified. Open Access
ARTICLES Gender‐dependent frequency of unconventional T cells in a healthy adult Caucasian population: A combinational study of invariant NKT cells, γδ T cells, and mucosa‐associated invariant T cells Parvind Singh, Marianna Szaraz-Szeles, Zoltan Mezei, Sandor Barath, Zsuzsanna Hevessy
Version of Record online:19 May 2022  Graphical Abstract Gender bias was investigated in frequency of unconventional T cells altogether, iNKT and γδ T cells showed gender dependent differences, unlike MAIT cells. Open Access
EDITORIAL COMMENTARY Stabilizing the immune system by chlorogenic acid Julia Kzhyshkowska
Version of Record online:19 May 2022  Graphical Abstract Discussion on mechanisms of a potent anti-inflammatory chlorogenic acid effect, and perspectives for new treatments of metabolic and inflammatory disorders. Open Access
EDITORIAL COMMENTARY Cold sensor, hot topic: TRPM8 plays a role in monocyte function and differentiation Brie Trusiano, Juselyn D. Tupik, Irving C. Allen
Version of Record online:15 May 2022  Graphical Abstract Discussion on TRPM8 function in monocyte differentiation and disease emphasizes the need for future characterization of cation channel mechanisms. ARTICLES Relationship and prognostic significance of IL‐33, PD‐1/PD‐L1, and tertiary lymphoid structures in cervical cancer Ying Zhang, Jing Li, Fan Yang, Xiying Zhang, Xiubao Ren, Feng Wei
Version of Record online:02 May 2022  Graphical Abstract IL-33, TLS and PD-L1 are potentially valuable prognostic predictor for cervical cancer. |
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