| JLB Vol 112 Issue 5 TOC |
ISSUE INFORMATION  Free Access
Issue InformationPages: 941-947 | First Published: 26 October 2022 EDITORIALS  Open Access
PMN‐MDSC in newborns: Regulation of the regulators Jadwiga Jablonska, Sven Brandau
Pages: 949-950 | First Published: 10 August 2022  Graphical Abstract Discussion on molecular mechanisms that regulate beneficial functions of transiently induced PMN-MDSC in newborn mice Open Access
Put them to bed, and “do not disturb” brain microglia in SIV infection Dennis Kolson
Pages: 951-953 | First Published: 16 August 2022  Graphical Abstract Discussion on the distinct brain myeloid cell response pathways in a study of SIV infection reveals a variable return of microglial homeostasis with virus suppression. SPOTLIGHT ON LEADING EDGE RESEARCH Mechanisms regulating transitory suppressive activity of neutrophils in newborns: PMNs‐MDSCs in newborns Michela Perego, Shuyu Fu, Yingjiao Cao, Andrew Kossenkov, Meng Yao, Erin Bonner, Kevin Alicea-Torres, Wangkai Liu, Zhilong Jiang, Zhihong Chen, Serge Y. Fuchs, Jie Zhou, Dmitry I. Gabrilovich
Pages: 955-968 | First Published: 21 June 2022  Graphical Abstract A mechanism of temporal control of PMN-MDSC in newborns identified that involves lactoferrin mediated positive and type I interferon mediated negative regulation. Open Access
Antiretroviral therapy restores the homeostatic state of microglia in SIV‐infected rhesus macaques Andrew J. Trease, Meng Niu, Brenda Morsey, Chittibabu Guda, Siddappa N. Byrareddy, Shilpa Buch, Howard S. Fox
Pages: 969-981 | First Published: 10 June 2022  Graphical Abstract ScRNA-seq of rhesus monkey microglia reveals clusters of cells in activated states in the setting of SIV infection, which is primarily reversed by suppressing viremia with combination antiretroviral therapy. REVIEWS Open Access
Physiologic roles of P2 receptors in leukocytes Anael Viana Pinto Alberto, Natiele Carla da Silva Ferreira, André Gustavo Calvano Bonavita, Oscar Kenji Nihei, Fernando Pires de Farias, Rodrigo da Cunha Bisaggio, Cristóvão de Albuquerque, Wilson Savino, Robson Coutinho-Silva, Pedro Muanis Persechini, Luiz Anastacio Alves
Pages: 983-1012 | First Published: 15 July 2022  Graphical Abstract Review of how purinergic P2 receptors expression and activation in leukocytes control the development of inflammation, infectious diseases, and pain. Metabolic regulation of type 2 immune response during tissue repair and regeneration Tian Ding, Shaohua Ge
Pages: 1013-1023 | First Published: 23 May 2022  Graphical Abstract Review on the metabolic regulation of immune cells involved in type 2 immunity and the role of these cells in tissue repair. Immune senescence and periodontitis: From mechanism to therapy Jiaqi Liu, Ruichen Dan, Xueman Zhou, Jie Xiang, Jun Wang, Jin Liu
Pages: 1025-1040 | First Published: 11 October 2022  Graphical Abstract : Review on the effects of immune cells and immune senescence on periodontitis. Galectin‐3 as a biomarker in breast neoplasms: Mechanisms and applications in patient care Doudou Georges Massar Niang, Folly Mawulolo Gaba, Adame Diouf, Jacobus Hendricks, Rokhaya Ndiaye Diallo, Maguette Deme Sylla Niang, Babacar Mbengue, Alioune Dieye
Pages: 1041-1052 | First Published: 20 September 2022  Graphical Abstract Review of the mechanisms involved in galectin-3 breast neoplasms promotion through the tumor microenvironment. COVID-19 INITIATIVE Free Access
Single‐cell immune profiling reveals long‐term changes in myeloid cells and identifies a novel subset of CD9+ monocytes associated with COVID‐19 hospitalization William J. Pandori, Lindsey E. Padgett, Ahmad Alimadadi, Norma A. Gutierrez, Daniel J. Araujo, Christine J. Huh, Claire E. Olingy, Huy Q. Dinh, Runpei Wu, Pandurangan Vijayanand, Serena J. Chee, Christian H. Ottensmeier, Catherine C. Hedrick
Pages: 1053-1063 | First Published: 22 July 2022  Graphical Abstract SARS-CoV-2 infection induces long-lasting changes in the myeloid cell compartment, and novel monocyte subsets, distinguished by expression of CD9 and Slan, correlate with COVID-19 severity. CELL DEVELOPMENT, DIFFERENTIATION AND TRAFFICKING Ginsenoside Rg1 ameliorates sepsis‐induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells Jun Guo, Rong Wang, Fei Min
Pages: 1065-1077 | First Published: 30 June 2022  Graphical Abstract Ginsenoside Rg1 exerted an alleviating effect on SI-AKI, likely resulting from the inhibition of ferroptosis in renal TECs through FSP1. RECEPTORS, SIGNAL TRANSDUCTION AND GENES IL‐17A produced by invariant natural killer T cells and CD3+CD56+αGalcer‐CD1d tetramer– T cells promote liver fibrosis in patients with primary biliary cholangitis Hongyu Jia, Jianing Chen, Xujun Zhang, Kefan Bi, Hetong Zhou, Tianxing Liu, Jia Xu, Hongyan Diao
Pages: 1079-1087 | First Published: 22 June 2022  Graphical Abstract Since IL-17A was produced by invariant natural killer T cells and CD3+CD56+αGalcer-CD1d tetramer- T cells promote PBC-related fibrosis, they could be potentially used as a novel target for immunotherapy in the patients with primary biliary cholangitis. INFLAMMATION, EXTRACELLULAR MEDIATORS AND EFFECTOR MOLECULES BRAF‐V600E utilizes posttranscriptional mechanisms to amplify LPS‐induced TNFα production in dendritic cells in a mouse model of Langerhans cell histiocytosis Danielle Minichino, Kaosheng Lv, Niansheng Chu, Wei Tong, Edward M Behrens
Pages: 1089-1104 | First Published: 01 June 2022  Graphical Abstract Hyperactive ERK signaling alters the DC translatome and TACE activity to amplify inflammatory responses to TLR4 stimuli, potentially contributing to inflammation in Langerhans Cell Histiocytosis in mice. Open Access
IL‐7 induces type 2 cytokine response in lung ILC2s and regulates GATA3 and CD25 expression Abdalla Sheikh, Julia Lu, Etienne Melese, Jung Hee Seo, Ninan Abraham
Pages: 1105-1113 | First Published: 23 May 2022  Graphical Abstract IL-7 is required for optimal IL-5, IL-13 and amphiregulin production in ILC2s during influenza/A infection; additionally, IL-7 regulates GATA3 in lung and bone marrow ILC2s. HOST DEFENSE AND PATHOPHYSIOLOGY IgM+ and IgM– memory B cells represent heterogeneous populations capable of producing class‐switched antibodies and germinal center B cells upon rechallenge with P. yoelii Susie L. Brown, Jonathan J. Bauer, Juhyung Lee, Enatha Ntirandekura, Jason S. Stumhofer
Pages: 1115-1135 | First Published: 03 June 2022  Graphical Abstract IgM+ and IgM- MBCs that co-express CD73 and CD80 can differentiate into plasmablasts and germinal center B cells after re-challenge with P. yoelii. Open Access
Notch regulates Histoplasma capsulatum clearance in mouse lungs during innate and adaptive immune response phases in primary infection Shuo Huang, George S. Deepe Jr.
Pages: 1137-1154 | First Published: 23 May 2022  Graphical Abstract Notch signaling dictates the function of dendritic cells and monocytes/macrophages in fungal infection. TRANSLATIONAL AND CLINICAL IMMUNOLOGY Open Access
Gender‐dependent frequency of unconventional T cells in a healthy adult Caucasian population: A combinational study of invariant NKT cells, γδ T cells, and mucosa‐associated invariant T cells Parvind Singh, Marianna Szaraz-Szeles, Zoltan Mezei, Sandor Barath, Zsuzsanna Hevessy
Pages: 1155-1165 | First Published: 19 May 2022  Graphical Abstract Gender bias was investigated in frequency of unconventional T cells altogether, iNKT and γδ T cells showed gender dependent differences, unlike MAIT cells. Achieving intracellular cytokine staining assay concordance on two continents to assess HIV vaccine‐induced T‐cell responses One B. Dintwe, Stephen C. De Rosa, Yunda Huang, Britta S. Flach, Bryce Manso, Don Carter, Faatima Laher Omar, Katharine V. Schwedhelm, Chenchen Yu, Huiyin Lu, Daryl Morris, Jia Jin Kee, Valentin Voillet, Michael Stirewalt, John Hural, Zoe Moodie, Nicole Frahm, Kristen W. Cohen, M. Juliana McElrath, Erica Andersen-Nissen
Pages: 1167-1181 | First Published: 22 July 2022  Graphical Abstract Outcomes of quality control for achieving inter-lab concordance of the ICS assay. Early differentiated CD28+ CD27+ T lymphocytes as a biomarker for short and long‐term outcomes in older patients with pneumonia Teresa Franco-Leyva, Olga H. Torres, María Encarnación Saez Prieto, Gemma Boera-Carnicero, Álvaro Santos, Sandra Clotet, Daniel Albert-Jares, Yasmin El-Ebiary, Manuela Agustí-Martí, Jordi Casademont, Cándido Juárez, Laura Martínez-Martínez
Pages: 1183-1190 | First Published: 23 June 2022  Graphical Abstract Increased levels of early differentiated CD28+ CD27+ T lymphocytes at admission for pneumonia in older people is a predictor of better survival and no hospital readmission. SYSTEM BIOLOGY AND IMMUNOGENETICS In silico design of a TLR4‐mediating multiepitope chimeric vaccine against amyotrophic lateral sclerosis via advanced immunoinformatics Kiarash Saleki, Mohamad Hosein Mohamadi, Mohamad Banazadeh, Parsa Alijanizadeh, Nima Javanmehr, Ramtin Pourahmad, Hamid Reza Nouri
Pages: 1191-1207 | First Published: 16 June 2022  Graphical Abstract Use of reverse vaccinology techniques to target multiple commonly misfolded proteins in ALS, such as SOD-1 and TDP-43. INFLAMMATION, EXTRACELLULAR MEDIATORS AND EFFECTOR MOLECULES GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium Julio Cesar Fernández-Ruiz, Fátima de Lourdes Ochoa-González, Martín Zapata-Zúñiga, Eduardo Mondragon-Marín, Edgar E. Lara-Ramírez, Jose Luis Ruíz-Carrillo, Paola Amayrani DelaCruz-Flores, Esther Layseca-Espinosa, José Antonio Enciso-Moreno, Julio Enrique Castañeda-Delgado
Pages: 1209-1221 | First Published: 27 September 2022  Graphical Abstract : GPR15/GPR15L interaction promotes leukocyte chemotaxis to synovium in patients with RA, this interaction might be a therapeutic target. Meeting: Targeted Science Issue - Macrophage Infection by HIV 2021 Guest Editors: Kiera Clayton, Janice Clements, and Mario Stevenson REVIEWS Open Access
Advancing basic and translational research to deepen understanding of the molecular immune‐mediated mechanisms regulating long‐term persistence of HIV‐1 in microglia in the adult human brain Thomas Boucher, Shijun Liang, Amanda M. Brown
Pages: 1223-1231 | First Published: 25 May 2022  Graphical Abstract Review focuses on human post-mitotic monocyte-derived microglia-like cells as tools to advance research on HIV persistence and neuroinflammatory signaling. Role of macrophages in HIV pathogenesis and cure: NIH perspectives Jeymohan Joseph, William Daley, Diane Lawrence, Eric Lorenzo, Peter Perrin, Vasudev R. Rao, Shang-Yi Tsai, Vasundhara Varthakavi
Pages: 1233-1243 | First Published: 08 September 2022  Graphical Abstract Overview of interests and activities of NIH institutes involved in supporting research on macrophages and HIV Clearance of HIV‐1 or SIV reservoirs by promotion of apoptosis and inhibition of autophagy: Targeting intracellular molecules in cure‐directed strategies Min Chen, Min Li, Marietta M. Budai, Andrew P. Rice, Jason T. Kimata, Mahesh Mohan, Jin Wang
Pages: 1245-1259 | First Published: 31 March 2022  Graphical Abstract Review on mechanisms for selective elimination of host cells harboring replication-competent HIV by a combination of latency reversal with inhibition of pro-survival anti-apoptotic molecules and autophagy. Mechanisms of HIV‐1 cell‐to‐cell transfer to myeloid cells Mingyu Han, Marie Woottum, Rémi Mascarau, Zoï Vahlas, Christel Verollet, Serge Benichou
Pages: 1261-1271 | First Published: 31 March 2022  Graphical Abstract Review of the mechanisms involved in HIV-1 cell-to-cell transfer to myeloid cells. Open Access
Current strategies to induce selective killing of HIV‐1‐infected cells Grant R. Campbell, Stephen A. Spector
Pages: 1273-1284 | First Published: 16 June 2022  Graphical Abstract Overview of current strategies to kill HIV-1-infected cells. Open Access
Animal models for studies of HIV‐1 brain reservoirs Emiko Waight, Chen Zhang, Saumi Mathews, Bhavesh D. Kevadiya, K. C. Kent Lloyd, Howard E. Gendelman, Santhi Gorantla, Larisa Y. Poluektova, Prasanta K. Dash
Pages: 1285-1295 | First Published: 31 August 2022  Graphical Abstract Review on recent rodent models that contain both human myeloid and T cells for future therapeutics and viral elimination investigations in CNS. Open Access
Shock and kill within the CNS: A promising HIV eradication approach? Marieke M. Nühn, Stephanie B. H. Gumbs, Ninée V. E. J. Buchholtz, Lisanne M. Jannink, Lavina Gharu, Lot D. de Witte, Annemarie M. J. Wensing, Sharon R. Lewin, Monique Nijhuis, Jori Symons
Pages: 1297-1315 | First Published: 23 September 2022  Graphical Abstract Review on the obstacles and limitations of using the shock and kill strategy to eradicate the HIV CNS reservoir. PRIMARY RESEARCH Morphine disrupts macrophage functions even during HIV infection John M. Barbaro, Matias Jaureguiberry-Bravo, Simone Sidoli, Joan W. Berman
Pages: 1317-1328 | First Published: 07 October 2022  Graphical Abstract : Morphine with or without ART dysregulates functions of primary human macrophages which may contribute to neuropathogenesis in opioid users living with HIV. Dysregulation of the IFN‐I signaling pathway by Mycobacterium tuberculosis leads to exacerbation of HIV‐1 infection of macrophages Maeva Dupont, Stella Rousset, Thien-Phong Vu Manh, Sarah Catherine Monard, Karine Pingris, Shanti Souriant, Zoï Vahlas, Tomàs Velez, Renaud Poincloux, Isabelle Maridonneau-Parini I, Olivier Neyrolles, Geanncarlo Lugo-Villarino, Christel Vérollet
Pages: 1329-1342 | First Published: 19 May 2022  Graphical Abstract Here, we identify a mechanism to explain why TB-derived type I-IFN is not able to induce antiviral immunity against HIV-1 in macrophages. Open Access
HIV‐1‐induced type I IFNs promote viral latency in macrophages Laura L. Dickey, Laura J. Martins, Vicente Planelles, Timothy M. Hanley
Pages: 1343-1356 | First Published: 19 May 2022  Graphical Abstract The molecular mechanisms by which macrophages induce HIV-1 latency were identified. |
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