JLB Vol 112, Issue 2

Cover Image Journal of Leukocyte Biology
Volume 112, Issue 2

Pages: 213-353

August 2022

 

ISSUE INFORMATION

Free Access
Issue Information

Pages: 213-217 | First Published: 23 July 2022

EDITORIAL

T‐Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction
Austin W Kerr, Philip A Efron, Shawn D Larson, Jaimar C Rincon

Pages: 219-220 | First Published: 28 April 2022

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Graphical Abstract

Discussion on how T-cell activation via TCR pathway impacts LPS-mediated inflammation and organ dysfunction.

SPOTLIGHT ON LEADING EDGE RESEARCH

T cell activation and IFNγ modulate organ dysfunction in LPS‐mediated inflammation
Matthew D. Taylor, Tiago D. Fernandes, Omar Yaipen, Cassidy E. Higgins, Christine A. Capone, Daniel E. Leisman, Ana Nedeljkovic-Kurepa, Mabel N. Abraham, Mariana R. Brewer, Clifford S. Deutschman

Pages: 221-232 | First Published: 09 February 2022

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Graphical Abstract

T cell activation reduces the lethal dose of lipopolysaccharide 10-fold with major alterations in the immunological responses, while causing similar clinical outcomes.

CELL DEVELOPMENT, DIFFERENTIATION AND TRAFFICKING

Effects of TNF‐α deletion on iNKT cell development, activation, and maturation in the steady‐state and chronic alcohol‐consuming mice
Hui Zhang, Faya Zhang, Samantha Modrak

Pages: 233-241 | First Published: 12 November 2021

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Graphical Abstract

TNF-a plays an important role in iNKT cell development, activation and maturation, and chronic alcohol consumption enhances iNKT cell activation and maturation through TNF-a.

RECEPTORS, SIGNAL TRANSDUCTION AND GENES

SUZ12 participates in the proliferation of PNH clones by regulating histone H3K27me3 levels
Yingying Chen, Hui Liu, Lijie Zeng, Liyan Li, Dan Lu, Zhaoyun Liu, Rong Fu

Pages: 243-255 | First Published: 06 January 2022

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Graphical Abstract

SUZ12 overexpression in abnormal clones in PNH patients regulates cell proliferation, apoptosis and the cell cycle by affecting the trimethylation level of H3K27 , thus conferring proliferation advantages to abnormal PNH clones, which then participate in the pathogenesis of PNH.

INFLAMMATION, EXTRACELLULAR MEDIATORS AND EFFECTOR MOLECULES

IRF3 inhibits IFN‐γ‐mediated restriction of intracellular pathogens in macrophages independently of IFNAR
Karolina Maciag, Raktima Raychowdhury, Karen Smith, Alexis M. Schneider, Jörn Coers, Maxwell R. Mumbach, Schraga Schwartz, Nir Hacohen

Pages: 257-271 | First Published: 26 November 2021

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Graphical Abstract

IRF3 modulates multiple responses of IFNγ-primed macrophages to intracellular bacteria, including production of nitric oxide; meanwhile, IFNγ reciprocally inhibits IRF3, contributing to immune homeostasis.

Open Access
The anti‐inflammatory peptide Catestatin blocks chemotaxis
Elke M. Muntjewerff, Kristel Parv, Sushil K. Mahata, N. Koen van Riessen, Mia Phillipson, Gustaf Christoffersson, Geert van den Bogaart

Pages: 273-278 | First Published: 22 December 2021

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Graphical Abstract

Catestatin blocks monocyte and granulocyte migration toward inflammatory chemokines.

Open Access
Immune modulatory effects of progesterone on oxLDL‐induced trained immunity in monocytes
Laszlo A. Groh, Dagmar E. Verel, Charlotte D.C.C van der Heijden, Vasiliki Matzaraki, Simone J.C.F.M. Moorlag, L. Charlotte de Bree, Valerie A.C.M. Koeken, Vera P. Mourits, Samuel T. Keating, Jelmer H. van Puffelen, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen

Pages: 279-288 | First Published: 17 January 2022

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Graphical Abstract

Cytokine production by oxLDL-induced trained immunity is inhibited by the steroid hormone progesterone.

HOST DEFENSE AND PATHOPHYSIOLOGY

Open Access
Crosstalk between R848 and abortive HIV‐1 RNA‐induced signaling enhances antiviral immunity
Melissa Stunnenberg, John L. van Hamme, Esther M. Zijlstra-Willems, Sonja I. Gringhuis, Teunis B.H. Geijtenbeek

Pages: 289-298 | First Published: 04 January 2022

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Graphical Abstract

Abortive HIV-1 RNA modulates TLR7/8-dependent signaling to induce effective antiviral innate and adaptive immunity in human dendritic cells.

SYSTEM BIOLOGY AND IMMUNOGENETICS

Open Access
Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy
Ruolan You, Diyu Hou, Bin Wang, Jingru Liu, Xiaoting Wang, Qirong Xiao, Zhipeng Pan, Dongliang Li, Xiaoming Feng, Lixia Kang, Ping Chen, Huifang Huang

Pages: 299-311 | First Published: 20 December 2021

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Graphical Abstract

Stromal contact renders AML cells chemoresistance by promoting AML cells' OXPHOS activity and OXPHOS's mechanism of action involves AMPK-mTORC1 pathway.

REVIEW

Open Access
Macrophage orchestration of epithelial and stromal cell homeostasis in the intestine
Qian Cao, Randall Tyler Mertens, Kisha Nandini Sivanathan, Xuechun Cai, Peng Xiao

Pages: 313-331 | First Published: 20 May 2022

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Graphical Abstract

This review focuses on how macrophages regulate intestine inflammation through cross-talking with epithelial cells and mesenchymal cells in the gut.

COVID-19 INITIATIVE

Free Access
Circulating B10 regulatory cells are decreased in severe and critical COVID‐19
Rodrigo Cervantes-Díaz, Víctor A. Sosa-Hernández, Sandra Romero-Ramírez, Jiram Torres-Ruiz, Alfredo Pérez-Fragoso, David E. Meza-Sánchez, Diana Gómez-Martín, José L. Maravillas-Montero

Pages: 333-337 | First Published: 24 February 2022

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Graphical Abstract

The B regulatory subset B10 (CD24hiCD27+IL-10+) was found depleted during severe/critical COVID-19 acute disease, negatively correlating with inflammatory parameters.

Open Access
Cross‐reactive cellular, but not humoral, immunity is detected between OC43 and SARS‐CoV‐2 NPs in people not infected with SARS‐CoV‐2: Possible role of cTFH cells
Álvaro Fernando García-Jiménez, Yaiza Cáceres-Martell, Daniel Fernández-Soto, Pedro Martínez Fleta, José M. Casasnovas, Francisco Sánchez-Madrid, José Miguel Rodríguez Frade, Mar Valés-Gómez, Hugh T. Reyburn

Pages: 339-346 | First Published: 05 April 2022

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Graphical Abstract

Deficiencies in T follicular cell responses may underlie the lack of cross-reactive antibodies between COVID-19 and seasonal coronaviruses.

LETTER TO THE EDITOR

Joost J. Oppenheim: 1934–2022
Sharon M. Wahl, Howard A. Young

Pages: 347-351 | First Published: 23 June 2022

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ERRATUM

Free Access
ERRATUM

Pages: 353 | First Published: 25 May 2022

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