| JLB Vol 111 Issue 6 TOC |
ISSUE INFORMATION  Free Access
Issue InformationPages: 1125-1129 | First Published:23 May 2022 EDITORIAL Neutropenia and infections: Neutrophil replacement through genetic engineering David C. Dale, Thomas H. Price
Pages: 1131-1132 | First Published:31 March 2022  Graphical Abstract Discussion of the 60-year history of development of granulocyte replacement therapies provides background for the report of Sykes et al in this issue of the Journal. SPOTLIGHT ON LEADING EDGE RESEARCH Transfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections David B. Sykes, Michelle M. Martinelli, Paige Negoro, Shuying Xu, Katrina Maxcy, Kyle Timmer, Adam L. Viens, Natalie J. Alexander, Johnny Atallah, Brendan D. Snarr, Shane R. Baistrocchi, Natalie J. Atallah, Alex Hopke, Allison Scherer, Ivy Rosales, Daniel Irimia, Donald C. Sheppard, Michael K. Mansour
Pages: 1133-1145 | First Published:31 March 2022  Graphical Abstract Engineered neutrophil progenitors protect against the invasive fungal pathogens, Candida and Aspergillus, in a neutropenic mouse model Free Access
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID‐19 Nathaniel L. Lartey, Salvador Valle-Reyes, Hilda Vargas-Robles, Karina E. Jiménez-Camacho, Idaira M. Guerrero-Fonseca, Ramón Castellanos-Martínez, Armando Montoya-García, Julio García-Cordero, Leticia Cedillo-Barrón, Porfirio Nava, Jessica G. Filisola-Villaseñor, Daniela Roa-Velázquez, Dan I Zavala-Vargas, Edgar Morales-Ríos, Citlaltepetl Salinas-Lara, Eduardo Vadillo, Michael Schnoor
Pages: 1147-1158 | First Published:26 November 2021  Graphical Abstract Inhibition of ADAM17 with apratastat or TMI-1 ameliorates neutrophilia and cytokine storm in a mouse model of Covid-19-related lung injury induced by poly(I:C) and the receptor-binding domain of the SARS-CoV2 Spike protein (RBD-S). Targeted Science Issue — Neutrophil 2021 Guest Editors: Edwin Chilvers, Alison Condliffe, Janet Lord, Stephen Renshaw, Adriano Rossi, Sonja Vermeren, and Sarah Walmsley REVIEWS Free Access
Neutrophil subsets and their differential roles in viral respiratory diseases Yuning Zhang, Quanbo Wang, Charles R Mackay, Lai Guan Ng, Immanuel Kwok
Pages: 1159-1173 | First Published:18 January 2022  Graphical Abstract Review on the role neutrophils play during viral respiratory diseases, evaluating their various pro- and anti- viral functions leading to disease resolution or pathology. PRIMARY RESEARCH Multifactorial assessment of neutrophil chemotaxis efficiency from a drop of blood Felix Ellett, Anika L. Marand, Daniel Irimia
Pages: 1175-1184 | First Published:31 January 2022  Graphical Abstract Dynamic sensitivity range of neutrophils to mechanical and chemical cues is determined. CELL DEVELOPMENT, DIFFERENTIATION AND TRAFFICKING Periodontal ligament stem cells promote polarization of M2 macrophages Jiani Liu, Hong Wang, Ludan Zhang, Xiaoyu Li, Xiaoling Ding, Gang Ding, Fulan Wei
Pages: 1185-1197 | First Published:04 January 2022  Graphical Abstract PDLSCs could promote M2 macrophage polarization and enhanced IL-4 and IL-13-induced M2 macrophage polarization via JNK pathways. Identification of liver‐specific CD24+ invariant NK T cells with low granzyme B production and high proliferative capacity Xiang Li, Chen Jin, Qi Chen, Xihua Zheng, Di Xie, Qielan Wu, Lu Wang, Shiyu Bai, Huimin Zhang, Li Bai
Pages: 1199-1210 | First Published:03 November 2021  Graphical Abstract Hepatic CD24+ iNKT cells show higher levels of proliferation, glucose metabolism and mTOR activity comparing to CD24- iNKT cells INFLAMMATION, EXTRACELLULAR MEDIATORS AND EFFECTOR MOLECULES Heparanase is a regulator of natural killer cell activation and cytotoxicity Alyce J Mayfosh, Katharine J Goodall, Tien Nguyen, Nikola Baschuk, Mark D Hulett
Pages: 1211-1224 | First Published:24 October 2021  Graphical Abstract Heparanase contributes to natural killer cell cytotoxicity, activation, and cytokine production HOST DEFENSE AND PATHOPHYSIOLOGY CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection Lulu Liu, Jinjin Zhong, Bilin Chen, Weiping Wang, Haiyan Xi, Xin Su
Pages: 1225-1234 | First Published:23 December 2021  Graphical Abstract CEBPD can regulate PTX3 during A. fumiagatus infection.  Open Access
PAD4 controls chemoattractant production and neutrophil trafficking in malaria Drinalda Cela, Sebastian Lorenz Knackstedt, Sarah Groves, Christopher M. Rice, Jamie Tae Wook Kwon, Benjamin Mordmüller, Borko Amulic
Pages: 1235-1242 | First Published:10 November 2021  Graphical Abstract PAD4 promotes malaria immunopathology by regulating chemokine production in macrophages and enhancing recruitment of inflammatory cells. TRANSLATIONAL AND CLINICAL IMMUNOLOGY Open Access
CCR7+ dendritic cells sorted by binding of CCL19 show enhanced Ag‐presenting capacity and antitumor potency Paul Burgoyne, Alan J Hayes, Rachel S Cooper, Michelle L Le Brocq, Christopher AH Hansell, John DM Campbell, Gerard J Graham
Pages: 1243-1251 | First Published:15 November 2021  Graphical Abstract Selection of CCR7+ DCs using chemically synthesized and tagged CCL19 selects a population of DC which improves anti-tumour immunity and efficacy in solid and metastatic tumour models. REVIEWS Epigenetic regulation of T cells by Polycomb group proteins Guilherme A. Melo, Carolina Calôba, Gabrielle Brum, Thaís O. Passos, Gustavo J. Martinez, Renata M. Pereira
Pages: 1253-1267 | First Published:25 April 2022  Graphical Abstract Review of how PRC1 and 2 regulate T cell development, differentiation and function. Direct and indirect regulation of the tumor immune microenvironment by VEGF Yuqing Zhang, Rolf A. Brekken
Pages: 1269-1286 | First Published:25 April 2022  Graphical Abstract Review on the function of vascular endothelial growth factor-A (VEGF) in regulating immune cells in the tumor microenvironment and theuse of anti-VEGF as cancer immunotherapy. COVID-19 INITIAITVE Free Access
Opposing roles for sMAdCAM and IL‐15 in COVID‐19 associated cellular immune pathology Amit Kumar Singh, Nandini Kasarpalkar, Shilpa Bhowmick, Gaurav Paradkar, Mayur Talreja, Karan Shah, Abhishek Tiwari, Harsha Palav, Snehal Kaginkar, Rajiv Kulkarni, Ashwini Patil, Varsha Kalsurkar, Sachee Agrawal, Jayanthi Shastri, Rajesh Dere, Ramesh Bharmal, Smita D. Mahale, Vikrant M. Bhor, Vainav Patel
Pages: 1287-1295 | First Published:24 January 2022  Graphical Abstract A mucosal and lymphocyte migration marker (sMAdCAM) and IL-15, a cytokine regulating leukocyte activation and homeostasis, are associated with different states of immune pathology following COVID-19. |
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