JLB Early View - April 2022

Cover Image Journal of Leukocyte Biology

Early View

Online Version of Record before inclusion in an issue

MEETING REVIEW

Mechanisms of HIV‐1 cell‐to‐cell transfer to myeloid cells
Mingyu Han, Marie Woottum, Rémi Mascarau, Zoï Vahlas, Christel Verollet, Serge Benichou

Version of Record online:31 March 2022

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Graphical Abstract

Review of the mechanisms involved in HIV-1 cell-to-cell transfer to myeloid cells.

Free Access

ARTICLES

Loss of mitochondrial membrane potential (ΔΨm) in leucocytes as post‐COVID‐19 sequelae
Karina Janice Guadalupe Díaz-Resendiz, Alma Betsaida Benitez-Trinidad, Carlos Eduardo Covantes-Rosales, Gladys Alejandra Toledo-Ibarra, Pablo Cesar Ortiz-Lazareno, Daniel Alberto Girón-Pérez, Adela Yolanda Bueno-Durán, Daniela Alejandra Pérez-Díaz, Rocío Guadalupe Barcelos-García, Manuel Iván Girón-Pérez

Version of Record online:31 March 2022

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Graphical Abstract

Patients recovered from COVID-19 present loss of the ΔΨm in HPBMC, leading to mitochondrial dysfunction, which is associated with the onset and progression of several chronic diseases such as pulmonary fibrosis, Alzheimer's, Parkinson's, and multiple sclerosis. Therefore, determining the ΔΨm in patients recovered from SARS-CoV-2 could be an early sign of several diseases caused by post-COVID-19 sequelae.

Open Access

ARTICLES

The SC cell line as an in vitro model of human monocytes
Amira Duweb, Ann-Kathrin Gaiser, Isabel Stiltz, Menna El Gaafary, Thomas Simmet, Tatiana Syrovets

Version of Record online:31 March 2022

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Graphical Abstract

Polarized SC-derived macrophages may with some restrictions serve as a model for M1 but not for M2 macrophages.

HIGHLIGHTED ARTICLE

Transfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections
David B. Sykes, Michelle M. Martinelli, Paige Negoro, Shuying Xu, Katrina Maxcy, Kyle Timmer, Adam L. Viens, Natalie J. Alexander, Johnny Atallah, Brendan D. Snarr, Shane R. Baistrocchi, Natalie J. Atallah, Alex Hopke, Allison Scherer, Ivy Rosales, Daniel Irimia, Donald C. Sheppard, Michael K. Mansour

Version of Record online:31 March 2022

Description unavailable
Graphical Abstract

Engineered neutrophil progenitors protect against the invasive fungal pathogens, Candida and Aspergillus, in a neutropenic mouse model

REVIEWS

Clearance of HIV‐1 or SIV reservoirs by promotion of apoptosis and inhibition of autophagy: Targeting intracellular molecules in cure‐directed strategies
Min Chen, Min Li, Marietta M. Budai, Andrew P. Rice, Jason T. Kimata, Mahesh Mohan, Jin Wang

Version of Record online:31 March 2022

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Graphical Abstract

Review on mechanisms for selective elimination of host cells harboring replication-competent HIV by a combination of latency reversal with inhibition of pro-survival anti-apoptotic molecules and autophagy.

EDITORIAL COMMENTARY

Neutropenia and infections: Neutrophil replacement through genetic engineering
David C. Dale, Thomas H. Price

Version of Record online:31 March 2022

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Graphical Abstract

Discussion of the 60-year history of development of granulocyte replacement therapies provides background for the report of Sykes et al in this issue of the Journal.

TECHNICAL ADVANCE

Robust engraftment of fetal nonhuman primate CD34‐positive cells in immune‐deficient mice
C.J. Little, W.J. Haynes, L. Huang, C.M. Daffada, K.B. Wolfe, E. Perrin, J.A. Simpson, J.A. Kropp Schmidt, H.M. Hinkle, L.T. Keding, R.T. Behrens, D.T. Evans, D.B. Kaufman, J.A. Thomson, T.G. Golos, M.E. Brown

Version of Record online:30 March 2022

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Graphical Abstract

Engraftment of rhesus macaque hematopoietic tissues in immune-deficient mice yields a robust BLT/NeoThy-type primatized mouse model for studying non-human primate hematopoiesis and immune function in vivo.

ARTICLES

K48‐ and K27‐mutant ubiquitin regulates adaptive immune response by affecting cross‐presentation in bone marrow precursor cells
Jun Jun Jia, Xiao Yan Liao, Yi Yun Liang, Rui Ling Chen, Feng Guang Gao

Version of Record online:30 March 2022

Description unavailable
Graphical Abstract

K48 and K27 ubiquitination contribute to regulating immune function of bone marrow precursor cells by affecting cross-presentation and thereby might be therapeutic target

ARTICLES

Tumor‐intrinsic CD21 expression impacts the response of B‐cell malignancy cells to CD19‐CAR‐T cells
Dan Li, Qiongyu Xu, Yutian Hu, Wenbing Wang, Shufeng Xie, Chunjun Zhao, Han Liu

Version of Record online:25 March 2022

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Graphical Abstract

Tumor-intrinsic CD21 impairs the target cell recognition and the cytotoxicity of the CD19-CAR-T cells.

ARTICLES

Gab2 promotes acute myeloid leukemia growth and migration through the SHP2‐Erk‐CREB signaling pathway
Rui Gong, Haoying Li, Yaqi Liu, Yanyan Wang, Lu Ge, Liuzhi Shi, Guang Wu, Jianxin Lyu, Haihua Gu, Licai He

Version of Record online:24 March 2022

Description unavailable
Graphical Abstract

Data to support model that Gab2 promotes AML progression through the SHP2-Erk-CREB pathway.

Free Access

ARTICLE - COVID-19 AND RELATED TOPICS

VIP plasma levels associate with survival in severe COVID‐19 patients, correlating with protective effects in SARS‐CoV‐2‐infected cells
Jairo R. Temerozo, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Camila R. R. Pão, Caroline S. de Freitas, Suelen Silva Gomes Dias, André C. Ferreira, Mayara Mattos, Vinicius Cardoso Soares, Lívia Teixeira, Isaclaudia G. Azevedo-Quintanilha, Eugenio D. Hottz, Pedro Kurtz, Fernando A. Bozza, Patrícia T. Bozza, Thiago Moreno L. Souza, Dumith Chequer Bou-Habib

Version of Record online:24 March 2022

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Graphical Abstract

In severe COVID-19 patients, VIP plasma levels correlated with decreased inflammatory markers and survival. In in vitro assays with monocytes and lung epithelial cells, VIP and PACAP were found to decrease SARS-CoV-2 RNA synthesis (monocytes) and viral replication (lung epithelial cells). Both neuropeptides also reduced inflammatory factors and cell death of infected cells.

REVIEWS

Microglial activation in Alzheimer's disease: The role of flavonoids and microRNAs
Elisa Medrano-Jiménez, Karla F. Meza-Sosa, José A. Urbán-Aragón, Ismael Secundino, Gustavo Pedraza-Alva, Leonor Pérez-Martínez

Version of Record online:16 March 2022

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Graphical Abstract

Review of how flavonoids control microglial activation states through regulation of microRNAs and the implications in Alzheimer's disease appearance and progression.

Open Access

ARTICLES

Cytokine responses to LPS in reprogrammed monocytes are associated with the transcription factor PU.1
Kedeye Tuerxun, Kristine Midtbö, Eva Särndahl, Egor Vorontsov, Roger Karlsson, Alexander Persson, Robert Kruse, Daniel Eklund, the X-HiDE Consortium

Version of Record online:13 March 2022

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Graphical Abstract

Differential cytokine response in endotoxin induced M-MDSC-like cells and their associated regulators.

MEETING REVIEW

Structures, functions, and inhibitors of LUBAC and its related diseases
Shuo Ning, Lingling Luo, Beiming Yu, Dina Mai, Feng Wang

Version of Record online:09 March 2022

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Graphical Abstract

Review on the structures, physiological functions, inhibitors of LUBAC, and related diseases caused by LUBAC aberration, providing comprehensively insight into LUBAC research.

REGULAR ARTICLE OR MANUSCRIPT

ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment
Spyridoula Tsiomita, Effrosyni Maria Liveri, Panagiota Vardaka, Angeliki Vogiatzi, Argyris Skiadaresis, George Saridis, Ioannis Tsigkas, Theologos M. Michaelidis, George Mavrothalassitis, George Thyphronitis

Version of Record online:08 March 2022

Description unavailable
Graphical Abstract

Erf transcriptional factor is a positive regulator of thymocyte maturation towards CD4 and CD8 commitment while negatively regulates γδ generation.

Open Access

ARTICLES

Characterization of memory T cell subsets and common γ−chain cytokines in convalescent COVID‐19 individuals
Anuradha Rajamanickam, Nathella Pavan Kumar, Arul Nancy Pandiaraj, Nandhini Selvaraj, Saravanan Munisankar, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Manoj Murhekar, Jeromie Wesley Vivian Thangaraj, Santhosh Kumar Muthusamy, Girish Kumar Chethrapilly Purushothaman, Tarun Bhatnagar, Manickam Ponnaiah, Sabarinathan Ramasamy, Saravanakumar Velusamy, Subash Babu

Version of Record online:08 March 2022

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Graphical Abstract

Our study provides evidence of alterations in lymphocyte counts, memory T cell subset frequencies and common γ-chain cytokines in convalescent COVID-19 individuals.

REGULAR ARTICLE OR MANUSCRIPT

Landscape of T Cells in NK‐AML(M4/M5) Revealed by Single‐Cell Sequencing
Wenqi Wu, Xiaolin Liang, Huiqun Li, Xiaoke Huang, Chengyao Wan, Qiongni Xie, Zhenfang Liu

Version of Record online:08 March 2022

Description unavailable
Graphical Abstract

Analysis of infiltrating T cells from NK-AML (M4/M5) patients using single-cell sequencing reveals distinct clusters and clonal expansion of immune T cells.

Open Access

HIGHLIGHTED ARTICLE

The cation channel TRPM8 influences the differentiation and function of human monocytes
Eve Hornsby, Hamish W. King, Madusha Peiris, Roberto Buccafusca, Wing-Yiu Jason Lee, Elinor S. Wing, L. Ashley Blackshaw, James O. Lindsay, Andrew J. Stagg

Version of Record online:01 March 2022

Description unavailable
Graphical Abstract

TRPM8 in human monocytes promotes aspects of their differentiation to macrophages and acts at a critical early time point to limit inflammatory potential.