JLB Early View November

Cover Image Journal of Leukocyte Biology

Early View

Online Version of Record before inclusion in an issue

REVIEWS

Gift bags from the sentinel cells of the immune system: The diverse role of dendritic cell‐derived extracellular vesicles
Amy L. Hodge, Amy A. Baxter, Ivan K. H. Poon

Version of Record online:26 October 2021


Graphical Abstract

Describes the functions of dendritic cell-derived extracellular vesicles in the context of antigen presentation, infection, cell death and immunotherapy.

ARTICLES

Heparanase is a regulator of natural killer cell activation and cytotoxicity
Alyce J Mayfosh, Katharine J Goodall, Tien Nguyen, Nikola Baschuk, Mark D Hulett

Version of Record online:24 October 2021


Graphical Abstract

Heparanase contributes to natural killer cell cytotoxicity, activation, and cytokine production

ARTICLES

NK cell‐based therapies for HIV infection: Investigating current advances and future possibilities
Arosh S. Perera Molligoda Arachchige

Version of Record online:20 October 2021


Graphical Abstract

Review of NK cell-based therapies for HIV infection

ARTICLES

Adoptive transfer of GRP78‐treated dendritic cells alleviates insulitis in NOD mice
Xiaoqi Zhou, Muyang Yang, Yibing Lv, Heli Li, Sha Wu, Jie Min, Guanxin Shen, Yong He, Ping Lei

Version of Record online:13 October 2021


Graphical Abstract

Adoptively transferred GRP78-DCs, specifically homed to the inflamed pancreas, can promote beta cell survival, alleviate insulitis, and resolve inflammation in NOD mice.

ARTICLES

Pro‐inflammatory polarization primes Macrophages to transition into a distinct M2‐like phenotype in response to IL‐4
Erin M. O'Brien, Kara L. Spiller

Version of Record online:13 October 2021


Graphical Abstract

M1 polarization primes macrophages to transition into a distinct M2 phenotype when compared with M2 macrophages derived from M0.

EDITORIAL COMMENTARY

Differential training of innate leukocytes getting compartmentalized
Shuo Geng, Liwu Li

Version of Record online:12 October 2021


Graphical Abstract

Discussion on the discovery of compartmentalized innate immune training, and its relevance for the general context of innate immune memory dynamics.

ARTICLES

Polymorphonuclear myeloid‐derived suppressor cells link inflammation and damage response after trauma
Xinyao Li, Jingping Liu, Zhe Xing, Jian Tang, Hengbiao Sun, Xiaogang Zhang, Shuaijun Lv, Ziyang Chen, Mengyu Shi, Meiqi Chen, Shaowen Zuo, Xiaoming Lyu, Yumei He

Version of Record online:12 October 2021


Graphical Abstract

Role of PMN-MDSCs in the anti-inflammatory immune response by regulation of the Treg/Th17 and Th2/Th1 balances after trauma.

ARTICLES

CTCF: A novel fusion partner of ETO2 in a multiple relapsed acute myeloid leukemia patient
Jiao Li, Zhen Shen, Zheng Wang, Hongying Chao, Yi Xu, Zhao Zeng, Xiaosen Bian, Jun Zhang, Jinlan Pan, Weiwei Miao, Wenzhong Wu, Li Yao, Suning Chen, Lijun Wen

Version of Record online:08 October 2021


Graphical Abstract

CTCF is a translocation partner of ETO2 in acute myeloid leukemia; aids in understanding the pathogenic mechanisms in AML and may have future prognostic value.

Open Access

BRIEF CONCLUSIVE REPORT

Transcription factor c‐Rel mediates communication between commensal bacteria and mucosal lymphocytes
Maik Luu, Kai Binder, Sabrina Hartmann, Meike Kespohl, Jasmin Bazant, Rossana Romero, Burkhard Schütz, Ulrich Steinhoff, Alexander Visekruna

Version of Record online:08 October 2021


Graphical Abstract

The transcription factor c-Rel regulates intestinal homeostasis and protects against pathogen colonization; c-Rel-deficient mice display defective IgA production in the intestine.

ARTICLES

Stem cells from exfoliated deciduous teeth transplantation ameliorates Sjögren's syndrome by secreting soluble PD‐L1
Ning Yang, Xuemei Liu, Xu Chen, Si Yu, Wenxiao Yang, Yao Liu

Version of Record online:08 October 2021


Graphical Abstract

Stem cells from human exfoliated deciduous teeth (SHED)-mediated rescue of Treg/Th17 balance via the sPD-L1/PD-1 pathway ameliorates the gland inflammation and dryness symptoms in SS mice, suggesting that SHED are a promising source for treating autoimmune diseases in a clinical setting.

REVIEWS

Immunoregulation by type I interferons in the peritoneal cavity
Jasmine J. M. Chuah, Paul J. Hertzog, Nicole K. Campbell

Version of Record online:06 October 2021


Graphical Abstract

Review of how peritoneal immune cells and type I interferons protect against or promote disease in the peritoneal cavity.

ARTICLES

Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell
Lin Li, Yuting Xia, Shijie Yuan, Fei Li, Xiaorong Xie, Yuan Luo, Xiang-Ping Yang, Ran He

Version of Record online:06 October 2021


Graphical Abstract

Blocking iron intake by anti-CD71 mAb impaired the response of TH17 cells, ameliorating autoimmune disease severity.

Open Access

ARTICLES

Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia
Anaísa V. Ferreira, Rienke F. Uijen, Ozlem Bulut, Marien I. de Jonge, Jorge Domínguez-Andrés, Mihai G. Netea

Version of Record online:01 October 2021


Graphical Abstract

Splenectomy allows for a largely intact innate immune memory response, except for the reduction of trained immunity- induced neutrophilia.