This review summarizes our research identifying mitochondrial pyruvate oxidative metabolism and its coupling to tricarboxylic (TCA) cycle resistance and disease tolerance energetics as pathway to sepsis survival.

Macrophages in the adipose tissue affect adipocyte functioning in the early life, thereby may have a long-term impact on obesity status.

Critically ill sepsis survivor patients show specific immunological endotypes, secondary to a persistent maladaptive reprioritization of myelopoiesis and pathological activation of myeloid cells.

Review of the current models to understand dynamic actions of macrophages in various diseases and new strategies to characterize their molecular network using single-cell transcriptomics.

Inflammatory acidosis represents a polarized neutrophil-epithelial dependent response independent of myeloperoxidase and ion efflux.

B cells secrete IgG antibodies through a pathways that promotes exposure to the enzyme Fut8 to promote N-glycan core fucosylation, yet limits exposure to ST6Gal1 to minimize alpha2,6 sialylation.

Th1 cells' function is suppressed in LUSC. Through scRNA-seq, the decreased Th1 cells' function is associated with ER stress, which requires further study.

Morphine with or without ART dysregulates functions of primary human macrophages, which may contribute to neuropathogenesis in opioid users living with HIV.

IL-33, TLS and PD-L1 are potentially valuable prognostic predictor for cervical cancer.

A neoimmunologic score system was constructed based on 4 variables including CD3+, CD8+, FoxP3+, and PD-1+ immune cell densities in non-small cell lung cancer.

Immune ecosystem of dengue infection analyzed to provide insights into the pathogenesis and treatment.

Single-cell resolution provide more precise biomarkers than usual which may substantially overcome intertumoral and intratumoral heterogeneity among Relapsed and Refractory DLBCL patients

This review provides a more comprehensive understanding of the biology of γδ cells and their role in CVD.

Graphical Abstract: Review on the molecular mechanisms of γδ T cells in liver disease and its implications for clinical immunotherapy.

Review of the characteristics, heterogeneity and mechanisms of γδ T cell exhaustion provides insights into the combined strategies to enhance γδ T cell-based anti-tumor immunotherapy.

Molecular mechanisms identified by which IL-1β/NF-κB down-regulates IGF-1 expression by let-7f-5p in dendritic epidermal T cells.

TIGIT expressing, ZOL-specific γδ T cells are not exhausted, but more functional in antitumor immune response.

p-JNK inhibitor treatment effectively revived human γδT cells from the apoptosis induced by IL-12/18 and maintained their enhanced IFN-γ production and cytotoxicity against tumor cells.