JLB Early View - March 2022

Cover Image Journal of Leukocyte Biology

Early View

Online Version of Record before inclusion in an issue
Open Access

ARTICLES

Kakonein restores hyperglycemia‐induced macrophage digestion dysfunction through regulation of cathepsin B‐dependent NLRP3 inflammasome activation
Dawei Lian, Li Zhu, Yunhong Yu, Xiaojuan Zhang, Yike Lin, Jiaying Liu, Ruifang Han, Yitong Guo, Dongpeng Cai, Wenjing Xiao, Yulin Chen, Hong He, Danping Xu, Chaoyang Zheng, Xiao Wang, Yi Huang, Yang Chen

Version of Record online:27 February 2022

Description unavailable
Graphical Abstract

Kakonein reduced the release of lysosomal cathepsin B and consequently inhibited NLRP3 inflammasome activation to prevent hyperglycaemia-associated dysfunction of macrophage digestion.

ARTICLES

Intrathymic SIRPa cDC subsets organization in normal and stress conditions reveal another level of cDCs heterogeneity
Victoria Michaels Lopez, Agnès Legrand, Emmanuel Tejerina, Jérome Megret, Chantal Bordin, Véronique Quellec, Sophie Ezine

Version of Record online:27 February 2022

Description unavailable
Graphical Abstract

Thymic SIRPa cDC subsets ontogeny and their interplays contribute to a suitable environment for T cell development

ARTICLES

Fatty acids secreted from head and neck cancer induce M2‐like Macrophages
Marwah M Albakri, Stanley Ching-Cheng Huang, Hammad N Tashkandi, Scott F Sieg

Version of Record online:25 February 2022

Description unavailable
Graphical Abstract

Fatty Acids from head and neck tumor cell lines mediate maturation of macrophages into cells with a limited pro-inflammatory phenotype.

Free Access

CONCISE REPORT

Circulating B10 regulatory cells are decreased in severe and critical COVID‐19
Rodrigo Cervantes-Díaz, Víctor A. Sosa-Hernández, Sandra Romero-Ramírez, Jiram Torres-Ruiz, Alfredo Pérez-Fragoso, David E. Meza-Sánchez, Diana Gómez-Martín, José L. Maravillas-Montero

Version of Record online:24 February 2022

Description unavailable
Graphical Abstract

The B regulatory subset B10 (CD24hiCD27+IL-10+) was found depleted during severe/critical COVID-19 acute disease, negatively correlating with inflammatory parameters.

REVIEWS

Circulating inflammatory cell profiling and periodontitis: A systematic review and meta‐analysis
Rizky A. Irwandi, Sandra O. Kuswandani, Simon Harden, Debora Marletta, Francesco D'Aiuto

Version of Record online:24 February 2022

Description unavailable
Graphical Abstract

Periodontitis and its treatment are associated with minor but consistent alterations in circulating inflammatory cell profiles. These changes could be a mechanism linking periodontitis to systemic diseases.

ARTICLES

The phosphoinositide‐3‐kinase (PI3K)‐delta inhibitor seletalisib impairs monocyte‐derived dendritic cells maturation, APC function, and promotes their migration to CCR7 and CXCR4 ligands
Fernanda Scopelliti, Laura Mercurio, Caterina Cattani, Valentina Dimartino, Cristina Albanesi, Gianfranco Costanzo, Concetta Mirisola, Stefania Madonna, Andrea Cavani

Version of Record online:24 February 2022

Description unavailable
Graphical Abstract

The study demonstrate that the PI3K-δ inhibitor Seletalisib impairs maturation of DCs while increasing expression of chemokine receptor involved in DC migration toward lymph nodes

REVIEWS

A curious case of cyclin‐dependent kinases in neutrophils
Ramizah Syahirah, Alan Y. Hsu, Qing Deng

Version of Record online:21 February 2022

Description unavailable
Graphical Abstract

CDK regulation of neutrophil function as a potential target in neutrophil-dominant inflammatory diseases.

ARTICLES

Synthesis and identification of lithocholic acid 3‐sulfate as RORγt ligand to inhibit Th17 cell differentiation
Riping Xiao, Kawai Lei, Hioha Kuok, Wende Deng, Yuxin Zhuang, Yanqing Tang, Zhengyang Guo, Hongyan Qin, Li-Ping Bai, Ting Li

Version of Record online:21 February 2022

Description unavailable
Graphical Abstract

Bile acid (BA) synthesis and cholesterol clearance pathway. Regulation of BA synthesis by feedback mechanism and BA transport through enterohepatic circulation. In the liver, cholesterol is metabolized to primary BAs (CA, CDCA) via primary pathway and alternative pathway, and conjugated with glycine or taurine, converted to TCA, GCA, GCDCA, and TCDCA. Primary BAs are transported to intestine via biliary excretion, and converted to secondary BAs (DCA, UDCA, LCA) by gut commensal bacteria, and conjugated with glycine or taurine, converted to GDCA, TUDCA, GUDCA, and GLCA. As the most common secondary BA, LCA is also oxidized to 3-oxo-LCA, or reabsorbed to the hepatocytes and converted into LCA-3-S in the liver. After conjugation, BAs are again excreted into the bile duct, completing the enterohepatic circulation. In the study, we explored that the sulfate of LCA, LCA-3-S, could bind to RORγt resulting in selectively inhibitory effect on Th17 cell differentiation, which might contribute to the prevention of cholestatic liver diseases.

ARTICLES

Genomic heterogeneity contributed to different prognosis between adult and pediatric acute lymphoblastic
Yanxin Chen, Yongzhi Zheng, Yunda Hong, Jingjing Wen, Jiazheng Li, Yan Huang, Yi Chen, Xiaoyun Zheng, Ting Yang, Yangqi Xu, Jing Zheng, Jianda Hu

Version of Record online:16 February 2022

Description unavailable
Graphical Abstract

Genomic landscape enhanced the understanding of the biological differences of ALL.

ARTICLES

Sterile inflammation alters neutrophil kinetics in mice
Alakesh Alakesh, Thiruvickraman Jothiprakasam, Jayashree V. Raghavan, Siddharth Jhunjhunwala

Version of Record online:16 February 2022

Description unavailable
Graphical Abstract

Inflammation causes an increase in neutrophil half-life at the inflammatory site and reduces bone marrow maturation time

BRIEF CONCLUSIVE REPORT

Neutrophil‐derived extracellular vesicles promote feed‐forward inflammasome signaling in cystic fibrosis airways
Osric A. Forrest, Brian Dobosh, Sarah A. Ingersoll, Sanjana Rao, Alexander Rojas, Julie Laval, Jessica A. Alvarez, Milton R. Brown, Vin Tangpricha, Rabindra Tirouvanziam

Version of Record online:16 February 2022

Description unavailable
Graphical Abstract

Blood neutrophils are reprogrammed upon entry into cystic fibrosis airways, releasing extracellular vesicles that can readily activate inflammasome signaling in naïve neutrophils and epithelial cells.

ARTICLES

Clinical utility of heparin‐binding protein as an acute‐phase inflammatory marker in interstitial lung disease
Mingshan Xue, Teng Zhang, Runpei Lin, Yifeng Zeng, Zhangkai Jason Cheng, Ning Li, Peiyan Zheng, Huimin Huang, Xiaohua Douglas Zhang, Hongman Wang, Baoqing Sun

Version of Record online:14 February 2022

Description unavailable
Graphical Abstract

HBP, which has the functions of inflammatory and fibrotic induction, as well as the advantage of pre-sythesis for faster release, is an important predictor of the risk of acute exacerbation of ILD.

Open Access

BRIEF CONCLUSIVE REPORT

Ascorbic acid attenuates activation and cytokine production in sepsis‐like monocytes
Tobias Schmidt, Robin Kahn, Fredrik Kahn

Version of Record online:09 February 2022

Description unavailable
Graphical Abstract

Ascorbic acid inhibits both the production of pro-inflammatory cytokines and the upregulation of CD16 and CD163 in LPS or LTA polarized monocytes in vitro.

HIGHLIGHTED ARTICLE

Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils
Leigha D. Larsen, Karen Dockstader, Courtney L. Olbrich, Ian M. Cartwright, Lisa A. Spencer

Version of Record online:09 February 2022

Description unavailable
Graphical Abstract

A dynamic continuum of CD11c expression provides a framework for tracking sub-phenotype versatility of intestinal eosinophils in health and disease.

HIGHLIGHTED ARTICLE

T cell activation and IFNγ modulate organ dysfunction in LPS‐mediated inflammation
Matthew D. Taylor, Tiago D. Fernandes, Omar Yaipen, Cassidy E. Higgins, Christine A. Capone, Daniel E. Leisman, Ana Nedeljkovic-Kurepa, Mabel N. Abraham, Mariana R. Brewer, Clifford S. Deutschman

Version of Record online:09 February 2022

Description unavailable
Graphical Abstract

T cell activation reduces the lethal dose of lipopolysaccharide 10-fold with major alterations in the immunological responses, while causing similar clinical outcomes.

Open Access

BRIEF CONCLUSIVE REPORT

DEK, a nuclear protein, is chemotactic for hematopoietic stem/progenitor cells acting through CXCR2 and Gαi signaling
Maegan L. Capitano, Yasser Sammour, James Ropa, Maureen Legendre, Nirit Mor-Vaknin, David M. Markovitz

Version of Record online:08 February 2022

Description unavailable
Graphical Abstract

The nuclear protein DEK acts as a chemotactic factor for hematopoietic stem and progenitor cells in a CXCR2- and Gαi protein-coupled signaling-dependent manner.

EDITORIAL COMMENTARY

Not all the same: Subtypes of mouse intestinal eosinophils in health and disease models
Mats W. Johansson

Version of Record online:07 February 2022

Description unavailable
Graphical Abstract

Discussion on mouse intestinal eosinophils before and after allergen challenge, and in a chronic inflammation model focusing on subtypes that differ in CD11c surface expression.

EDITORIAL COMMENTARY

Kindlin‐3 puts the brakes on B cell activation and differentiation
Louis B. Justement

Version of Record online:03 February 2022

Description unavailable
Graphical Abstract

Discussion on the role of kindlin-3 in regulation of integrin function, B cell homing, cross-talk with the CXCR5:CXCL13 axis and B cell activation.