JLB Early View September 2021

Cover Image Journal of Leukocyte Biology

Early View

Online Version of Record before inclusion in an issue

ARTICLE

Adipose‐derived stem cell‐derived extracellular vesicles inhibit neuroblastoma growth by regulating GABBR1 activity through LINC00622‐mediated transcription factor AR
Mengguo Guo, Dongpeng Li, Yawen Feng, Mu Li, Bo Yang

Version of Record online: 27 August 2021


Graphical Abstract

Adipose-derived stem cell-derived extracellular vesicles inhibited neuroblastoma (NB) cell growth by carrying LINC00622 into NB cells to inhibit transcription factor androgen receptor and to promote gamma-aminobutyric acid B-type receptor 1 expression.

Open Access

ARTICLES

Pulmonary and blood dendritic cells from sarcoidosis patients more potently induce IFNγ‐producing Th1 cells compared with monocytes
Rico Lepzien, Mu Nie, Paulo Czarnewski, Sang Liu, Meng Yu, Avinash Ravindran, Susanna Kullberg, Anders Eklund, Johan Grunewald, Anna Smed-Sörensen

Version of Record online: 25 August 2021


Graphical Abstract

Blood and pulmonary dendritic cells from sarcoidosis patients more potently induced a T cell response with Tbet expression and IFNγ production compared with monocytes.

Open Access

BRIEF CONCLUSIVE REPORT

The WASp L272P gain‐of‐function mutation alters dendritic cell coordination of actin dynamics for migration and adhesion
Mariana M.S. Oliveira, Shin-Yu Kung, Hélène D. Moreau, Mathieu Maurin, Julien Record, Doriane Sanséau, Susanne Nylén, Ana-Maria Lennon-Duménil, Lisa S. Westerberg

Version of Record online: 25 August 2021


Graphical Abstract

WASp activity regulates dendritic cell (DC) migration; DCs have a remarkable adaptation for migration under inflammatory conditions in vivo.

BRIEF CONCLUSIVE REPORT

Neutrophil function and bactericidal activity against Staphylococcus aureus after cardiac surgery with cardiopulmonary bypass
Mathieu Lesouhaitier, Murielle Gregoire, Arnaud Gacouin, Valentin Coirier, Aurélien Frerou, Caroline Piau, Vincent Cattoir, Erwan Dumontet, Matthieu Revest, Pierre Tattevin, Antoine Roisne, Jean-Philippe Verhoye, Erwan Flecher, Yves Le Tulzo, Karin Tarte, Jean-Marc Tadié

Version of Record online: 23 August 2021


Graphical Abstract

Cardiopulmonary bypass does not immediately affect neutrophils functions.

MEETING ARTICLES

Sinomenine increases adenosine A2A receptor and inhibits NF‐κB to inhibit arthritis in adjuvant‐induced‐arthritis rats and fibroblast‐like synoviocytes through α7nAChR
Lang Yi, Junyu Ke, Jiayan Liu, Huili Lai, Yanjun Lv, Chong Peng, Yingkun Zhi, Qun Du, Liang Liu, Peixun Wang, Hua Zhou, Yan Dong

Version of Record online: 23 August 2021


Graphical Abstract

Sinomenine increased adenosine receptor A2A and inhibited the activation of the NF-κB pathway via the alpha7 nicotinic acetylcholine receptor in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes.

MEETING ARTICLES

Histone methyltransferase Ezh2 negatively regulates NK cell terminal maturation and function
Minghang Yu, Ziyang Su, Xuefeng Huang, Yujie Zhou, Xulong Zhang, Bingbing Wang, Zihan Wang, Yi Liu, Nianzeng Xing, Miaoran Xia, Xi Wang

Version of Record online: 23 August 2021


Graphical Abstract

Deletion of Ezh2 promotes NK cell terminal differentiation and cytotoxicity with increased IFN-γ production by a potential target Pbx1.

MEETING ARTICLES

Multi‐omics analysis of the expression and prognostic value of the butyrophilins in breast cancer
He Ren, Shuliang Li, Xin Liu, Wanjing Li, Jianlei Hao, Na Zhao

Version of Record online: 19 August 2021


Graphical Abstract

Exploring the biological roles of the butyrophilins gene family provides new insight into cancer pathogenesis and breast cancer prognosis.

ARTICLES

Interference with long noncoding RNA SNHG3 alleviates cerebral ischemia‐reperfusion injury by inhibiting microglial activation
Dezhang Huang, Yanbin Cao, Tingting Zu, Jianghua Ju

Version of Record online: 19 August 2021


Graphical Abstract

Interference with lncRNA SNHG3 is involved in cerebral ischemia-reperfusion injury by inhibiting microglial activation and the secretion of pro-inflammatory factors (TNF-α and IL-6). LncRNA SNHG3 could bind and stabilize HDAC3 protein, and inhibit the ubiquitination of HDAC3.

REVIEWS

Role of IL‐6 in dendritic cell functions
Yu-Dong Xu, Mi Cheng, Pan-Pan Shang, Yong-Qing Yang

Version of Record online: 18 August 2021


Graphical Abstract

Reviews the role of IL-6, when generated in an inflammatory context or as derived from dendritic cells (DCs), in modulating the biological function and activation status of DCs.

REVIEWS

Stem cell‐like memory T cells: The generation and application
Yutong Wang, Feng Qiu, Yifan Xu, Xiaorui Hou, Zhili Zhang, Lei Huang, Huijun Wang, Hui Xing, Sha Wu

Version of Record online: 17 August 2021


Graphical Abstract

The induction and clinical application of stem like memory T cells suggest its promising protective and theraputic usage.

ARTICLES

High mobility group box‐1 serves a pathogenic role in spinal cord injury via the promotion of pro‐inflammatory cytokines
Ke-Bing Chen, Min-Min Chang, Sheng-Li Wang, Yong-Xin Li, Yi-Xi Wang, Zhi-Guang Xu, Hong Wang, Bing-Cheng Zhao, Wei-Ying Ma

Version of Record online: 17 August 2021


Graphical Abstract

HMGB1 served an important role in SCI inflammation and the therapeutic potential of an anti-HMGB1 antibody for SCI.

ARTICLES

Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage phenotypes
Catherine B. Anders PhD, Tyler M.W. Lawton, Hannah L. Smith, Jamie Garret, Margaret M. Doucette DO, Mary Cloud B. Ammons PhD

Version of Record online: 09 August 2021


Graphical Abstract

Macrophage functional plasticity of six macrophage phenotypes correlates with unique distinctions in cell-surface marker expression, signal protein secretion, transcriptomics profiles, and metabolic processes.

Open Access

ARTICLES

Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions
Rita Silva-Gomes, Sarah N. Mapelli, Marie-Astrid Boutet, Irene Mattiola, Marina Sironi, Fabio Grizzi, Federico Colombo, Domenico Supino, Silvia Carnevale, Fabio Pasqualini, Matteo Stravalaci, Rémi Porte, Andrea Gianatti, Constantino Pitzalis, Massimo Locati, Maria José Oliveira, Barbara Bottazzi, Alberto Mantovani

Version of Record online: 04 August 2021


Graphical Abstract

MS4A tetraspan molecules are differentially expressed and regulated in myeloid cells under normal and pathological conditions.

ARTICLES

Novel neutrophil phenotypic signature in pediatric patients with type 1 diabetes and diabetic ketoacidosis
Blake E Nichols MD, Jessica S Hook, Kayson Weng, Chul Ahn PhD, Jessica G Moreland MD

Version of Record online: 03 August 2021


Graphical Abstract

Neutrophils from pediatric patients with diabetic ketoacidosis display a primed phenotype at baseline, but fail to prime further when stimulated with TNF-α.

ARTICLES

Plasma extracellular vesicles released after severe burn injury modulate macrophage phenotype and function
Micah L. Willis, Cressida Mahung, Shannon M. Wallet, Alexandra Barnett, Bruce A. Cairns, Leon G. Coleman Jr., Robert Maile

Version of Record online: 03 August 2021


Graphical Abstract

Extracellular vesicles released into the plasma after severe burn injury transduce dysfunctional immune signaling in naive mice and macrophages similar to the clinical course after burn.