Graphical Abstract:

Macrophages are indispensable in the process of BCP-induced new bone formation, where M2 macrophages are promoted through the sustained supply of BCP-released Ca²⁺ to CaSR.

Discussion on how single-cell technology advances tumor immunology and immunotherapy research.

Up-regulated expression and activation of STAT5 increases GM-CSF expression, promotes neutrophil augmentation, and eventually exacerbates chronic pancreatitis.

Fecal eosinophil-derived neurotoxin (F-EDN) levels are correlated to degranulation of eosinophils in the colon of irritable bowel syndrome (IBS) patients.

Discussion on the increase in nonclassical monocytes in patients with DADA2 as shown by scRNA seq; these pro inflammatory cells also show increased TNFR2, type I, and type II IFN pathway gene expression.

Shows the importance of immune regulation in oral submucous fibrosis (OSF); examines T lymphocytes, B lymphocytes, dendritic cells, mast cells, and related immune complexes and their roles in the pathogenesis and treatment of OSF.

Unconventional T cells and NK cells require IL-12, monocytes, conventional T cells, and a mature immune system to efficiently respond to Staphylococcal enterotoxins in vitro.

MiR-155 regulates pulmonary formation of NETs in abdominal sepsis via PAD4 upregulation and histone 3 citrullination; miR-155 could be a useful target to reduce pulmonary damage in abdominal sepsis.

Resting human monocytes have intracellular storage pools of CCL5 that are associated with compartments containing Rab11A and CD63, enabling rapid release without the need for de novo protein synthesis.

The pyroptosis caused by diabetes leads to the dysfuntion of macrophages and the establishment of a pro-inflammatory, pre-aging microenvironment.

Deficiency of the small GTPase Gem slows down the autophagic flux in stimulated neutrophils, causing autophagosome accumulation and autophagosome-associated NADPH complex assembling, leading to increased ROS and NETs formation.

Reviews the role of neutrophils in preventing amoebiasis.

This work intends to declare what metabolic alterations happen in MDSCs to support their physiologic and functional demands under a variety of pathologic situations.

Taurine up-regulated gene 1 (TUG1) reduces endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells and ameliorates diabetic nephropathy by inhibiting transcription factor PU.1.

A novel TREM2 splicing isoform constitutes up to 35 percent of transcript repertoire in human brain and encodes protein with activities different from the canonic isoform